Interaction between Schwann cells and other cells during repair of peripheral nerve injury

Peripheral nerve injury (PNI) is common and, unlike damage to the central nervous system injured nerves can effectively regenerate depending on location and severity of injury. myelinating glia, Schwann cells (SCs), interact with various in around site are important for debris elimination, repair, regeneration. Following PNI, Wallerian degeneration distal stump rapidly initiated by damaged axons followed morphologic changes SCs recruitment circulating macrophages. Interaction fibroblasts from microenvironment also plays a role repair. The replication migration injury-induced dedifferentiated repairing nerve. In particular, SC stimulates axonal regeneration subsequent myelination regenerated fibers. This mobility increases interactions other exogenous environment, which influence behavior post-injury. directly indirectly SCs, fibroblasts, addition, inter- intracellular mechanisms that underlie morphological functional following PNI still require further research explain known phenomena less understood cell-specific roles repair peripheral review provides basic assessment function post-PNI, as well more comprehensive evaluation literature concerning macrophages ultimately,